Should you’ve heard of billionaire Bryan Johnson, you’ve doubtless encountered the phrase “bio age testing.”
Johnson, the topic of the Netflix documentary Don’t Die, says he’s on a quest to realize the bottom attainable “organic age” (often known as bio age).
He reportedly spends thousands and thousands every year on anti-aging remedies—dozens of every day dietary supplements, weekly acid peels for his pores and skin, injections to spice up collagen manufacturing, hyperbaric oxygen remedy, and plasma infusions extracted from his 17-year-old son’s physique.
To find out what’s working, Johnson has undergone quite a few checks to evaluate his bio age. Johnson says these checks present his age is now 5.1 years youthful than when he launched into his anti-aging quest.
Apparently, he’s growing older in reverse.
Granted, not everybody’s shopping for it. A New York Instances exposé, for instance, claims Johnson’s organic age, in actuality, has elevated by 10 years.1
Nonetheless, Johnson’s “don’t die” campaign is gaining traction.
Bio age checks are a frequent matter on fashionable podcasts by Peter Attia, Joe Rogan, and Andrew Huberman. Google “bio age testing” and also you’ll see dozens of advertisements for mail-order blood or urine testing kits that declare to disclose your organic age, tempo of growing older, and extra. With costs tumbling into affordability, it’s pure to surprise…
Do you have to or your consumer join bio age testing?
In that case, which take a look at is finest? Simply as importantly, what must you do with the knowledge?
On this story, you’ll study:
What’s your bio age?
Your organic age (bio age) refers to how your cells perform. It’s not essentially the identical as your chronological age, which refers back to the variety of candles in your birthday cake.
For instance, let’s say Chang, a 50-year-old man, works at a desk, spends his free time in entrance of the TV, lives in essentially the most polluted metropolis on the planet, eats a sweet bar for lunch, and smokes. Alternatively, Jabari, a unique 50-year-old man, hits the gymnasium a number of instances every week, lives within the mountains, doesn’t smoke, relishes his 5 servings of veggies a day, meditates, and spends most evenings in his backyard.
Genetics apart, you’d be clever to wager that Jabari’s bio age is youthful than Chang’s.
How do these checks measure bio age?
Bio age testing kits measure a number of organic markers of growing older, often known as biomarkers.
For instance, some checks concentrate on the scale of your telomeres, the protecting caps on the ends of chromosomes. Others measure DNA methylation, a physiological course of that chemically alters DNA.
As soon as an organization isolates and measures these markers out of your blood or urine, it plugs the bio knowledge right into a formulation that calculates your bio age.
Nonetheless, should you see a physician with any regularity, you’re doubtless already monitoring some biomarkers of growing older. For instance, biomarkers similar to blood stress, levels of cholesterol, and blood glucose may also help predict your danger of future heart problems, a number one reason behind untimely demise.
What’s the purpose of biomarker testing?
Biomarker testing may also help you monitor your wellness proactively fairly than ready for illness signs to look.
For some, it additionally serves as a motivator. Should you study you have got the bones of somebody 20 years older, this will likely provide the nudge it’s essential to begin energy coaching constantly.
As well as, biomarkers present goal knowledge, permitting you to trace and consider varied health-related actions quantitatively. By monitoring your blood stress, you would possibly study that constant train helps, however your late-afternoon vitality drink does the other.
5 FREE biomarker checks
You don’t should be a billionaire (or perhaps a millionaire) to trace biomarkers of growing older.
On this part, we’ll cowl a number of massively underappreciated, scientifically validated checks you should utilize to realize perception into your bio age—for FREE.
Earlier than scientists developed high-tech blood-based bio age checks, researchers used these free checks to calculate the tempo of growing older within the individuals they studied.
FREE biomarker take a look at #1: Get off the ground
People who find themselves fitter and stronger are inclined to reside longer.2
That’s as a result of muscle groups do extra than simply transfer us round. Additionally they secrete anti-inflammatory substances, assist to manage blood sugar, sluggish mobile growing older, shield the liner of the arteries, and extra. All this helps scale back the danger of age-related ailments, similar to kind 2 diabetes, hypertension, and coronary heart illness, a phenomenon we discover in our article, The New Science of Muscle.
Associated to energy, your capability to steadiness can also be key. Should you’re middle-aged or older and may’t stand on one foot for at the least 10 seconds, your danger of dying within the subsequent seven years is double that of somebody who can stand for longer, in line with a research of 1,700 individuals.3
The Sitting-Rising Take a look at (SRT) is one option to assess each energy and steadiness on the identical time.
Individuals with low scores on this take a look at have the next danger of dying from heart problems, in line with a 12-year research of 4,200 adults between the ages of 46 and 75.4
▶ The best way to measure it
Decrease your self to the ground along with your legs in a crisscross place. Then, along with your legs in the identical place, stand again up. As you stand, discover should you should use part of your physique—hand, shin, knee—as leverage.
To attain your self, begin with 10 factors. Then, for every physique half you used to face, deduct some extent. Subtract a half level should you grew to become unsteady or misplaced your steadiness.
Understand that this (and different checks) function a proxy to your health. A low rating signifies that your steadiness and coordination, muscle energy and energy, and mobility might all require some consideration.
FREE biomarker take a look at #2: Squeeze a ball
Just like the SRT take a look at, your grip energy supplies perception into your general health. If the muscle groups in your palms are weak, the muscle groups all through your physique usually tend to be weak, too.
Poor grip energy also can predict future muscle weak point. In a single research, individuals with a weak grip had been extra prone to stroll slowly and be unable to rise from a chair, full rigorous housekeeping, or climb a flight of steps 25 years later.5
Low grip energy has additionally been related to:6
- Low bone mineral density
- Elevated danger of falls
- Poor dietary standing
- Melancholy
- Poor sleep, cognitive perform, and/or high quality of life
- Elevated danger of coronary heart illness, most cancers, and untimely mortality
In response to one research, grip energy was a greater indicator of longevity (or lack thereof) than blood stress.7
▶ The best way to measure it
Seize an ordinary tennis ball, and squeeze as laborious as you may, for so long as you may.
Should you can handle 15 to 30 seconds earlier than your grip fatigues, you’re doing high quality. Ninety seconds places you nicely above common—something over 90 ranks you solidly within the upper-third percentile.
Should you’re under 15, understand that this take a look at can also be only one indicator of your general energy. (And squeezing balls to enhance grip energy with out coaching the remainder of your physique is unlikely to make important enhancements in your general well being and health.)
A hand-held dynamometer—out there to be used at most occupational therapists’ and a few gyms—also can take a look at grip energy. (Should you’re keen to shell out some money, you should buy your individual for someplace between $100 and $500.)
FREE biomarker take a look at #3: Stand on one foot
A capability to steadiness on one foot for an prolonged interval may also help scale back your danger of falls, one of many main causes of injury-related demise amongst older adults.
As well as, many alternative bodily methods—the eyes, interior ear, skeletal muscle groups, and mind—should work collectively that can assist you keep upright.
Circumstances like diabetes, coronary heart illness, and most cancers can all have an effect on steadiness. Because of this, an incapacity to face on one foot can function a warning signal for eroding well being and health.8
▶ The best way to measure it
Stand close to a wall or chair for security. Hold your eyes open and palms in your hips. Then, carry your dominant leg and begin timing your self. As soon as you set your foot down, cease the clock. Repeat the take a look at along with your non-dominant leg.
Upon getting your instances, evaluate them to the next averages, from a research out of Duke College, to see how you probably did in comparison with your age-matched friends.9
Age | Seconds on one leg (males) | Seconds on one leg (females) |
---|---|---|
30-39 | 59 | 56 |
40-49 | 56 | 55 |
50-59 | 42 | 48 |
60-69 | 40 | 38 |
70-79 | 27 | 25 |
80+ | 13 | 11 |
FREE biomarker take a look at #4: How you are feeling
Generally you realize why you’re drained, such because the morning after binge-watching the previous few episodes of a thriller. When you compensate for your sleep, the weariness lifts.
That’s not the identical factor as fatigue, which describes persistent exhaustion that worsens over time and interferes with life. Along with feeling bodily drained, somebody who’s fatigued feels mentally boring and emotionally exhausted.
Consider fatigue as an early signal that one thing’s off, particularly should you don’t know the trigger.
Let’s say you’ve already dominated out the same old suspects like an excessive amount of caffeine, dehydration, an excessive amount of alcohol, remedy unintended effects, continual stress, or an excessive amount of or too little train. What’s left is probably going a sleep problem or a creating well being downside similar to anemia, weight problems, despair, most cancers, or diabetes, to call a couple of.
Should you’re 60 or older, fatiguability—or how worn out you are feeling after an exercise—also can predict longevity.
In response to analysis out of the College of Pittsburgh Medical Middle, the upper somebody scores in fatiguability, the upper their danger of demise sooner or later.10 Different analysis has linked excessive fatiguability with declines in gait pace, strolling capability, and different checks of health.11
▶ The best way to measure it
To measure fatigability, use a software referred to as the Pittsburgh Fatigability Scale. Utilizing a 0 (no fatigue) to five (excessive fatigue) scale, fee how fatigued you suppose you’ll really feel after finishing the next actions:
Exercise | Length | Rating (0 to five) |
---|---|---|
Leisurely strolling | half-hour | |
Brisk or quick strolling | 1 hour | |
Mild family exercise | 1 hour | |
Heavy gardening or yard work | 1 hour | |
Watching tv | 2 hours | |
Sitting quietly | 1 hour | |
Average-to-high depth energy coaching | half-hour | |
Taking part in a social exercise | 1 hour | |
Internet hosting a social occasion for 60 minutes | 1 hour | |
Excessive depth exercise | half-hour | |
Add all scores: |
Should you rating lower than 15, you’re doing nicely. Scores between 15 and 24 are a warning signal. Something 25 and above is considered extreme, and price mentioning to your healthcare skilled.12
FREE biomarker take a look at #5: Physique composition
Regardless of fashionable perception, each too little and an excessive amount of physique fats can affect well being for the more serious, as we discover in our infographic, Is physique fats good or dangerous for you?
An excessive amount of fats raises the danger for: | Too little muscle raises danger for: |
---|---|
Coronary heart illness | Coronary heart illness |
Hypertension | Hypertension |
Most cancers | Most cancers |
Fatty liver illness | Stroke |
Insulin resistance | Insulin resistance |
Sort 2 diabetes | Quicker mobile growing older |
Irritation | Irritation |
Joint misery | Melancholy and nervousness |
Sleep apnea | Falls and lack of steadiness |
Your muscle mass additionally performs a task, which is why somebody’s physique composition issues greater than their weight.
The gold commonplace strategies that estimate physique composition—underwater weighing, air displacement (Bod Pod), and dual-energy X-ray absorptiometry (DEXA)—actually aren’t free.
Nonetheless, a latest research decided {that a} good old style (and low cost) tape measure can present a comparably correct estimate of physique composition.13
▶ The best way to measure it
To make use of a tape measure to maintain observe of your physique fats proportion, measure:
- The widest a part of your neck
- The narrowest a part of your waist (For some individuals, this will likely be on the navel. For others, it could be barely above the navel)
- The widest a part of your hips
Make sure the tape is comfortable however not so tight that it cuts into the pores and skin. Upon getting your measurements, plug these numbers—alongside along with your age, intercourse, top, and weight—into our FREE Physique Fats Calculator, which can take it from there.
Physician-approved biomarker checks
Relying on the place you reside on the planet, the next checks might not be free. Nonetheless, as a part of routine preventative care, your insurance coverage would possibly cowl them.
Physician-approved take a look at #1: Blood panel
In case your main care physician recommends yearly blood work, it’s for good cause.
By maintaining tabs on a number of blood markers, you may see in case your well being is trending towards kind 2 diabetes or coronary heart illness, each main causes of untimely mortality.
Many blood markers may also be influenced comparatively rapidly (inside 6 to 12 weeks) via way of life modifications, complement protocols, or medicines. This makes them sensible instruments for monitoring whether or not varied way of life or medical modifications are working.
▶ The best way to measure it
Should you’re not already doing so, contemplate having the next blood markers examined yearly. Then, speak to your well being care skilled about what your numbers imply. They could use the next numbers, alongside along with your blood stress, to calculate a heart problems danger rating.
Blood marker | Optimum vary |
---|---|
Whole ldl cholesterol | < 200 mg/dL* |
LDL | < 100 mg/dL for these with out coronary heart illness < 70 mg/dL for these with a historical past of coronary heart assault or stroke |
HDL | > 60 mg/dL |
Triglycerides | < 150 mg/dL |
Alipoprotein B (Apo B) | < 133 mg/dL (males) < 117 mg/dL (females) |
Lipoprotein (a) | < 30 mg/dL |
C-reactive protein | < 2.0 mg/L** |
Fasting glucose | < 100 mg/dL |
Hemoglobin A1C | < 5.7% |
*Milligrams per deciliter of blood
**Milligrams per liter
Physician-approved take a look at #2: Bone density
When researchers research wholesome super-agers aged 90 and older, sturdy bones are one among their defining options.14
Which may be as a result of, like muscle groups, bones are reside organs that secrete substances which may be helpful to general well being and longevity.15
For instance, bones secrete osteocalcin, a hormone that performs a task in bone transforming. When osteocalcin circulates within the physique, it’s thought to play a task in every little thing from serving to muscle groups to supply ATP to regulating mind neurotransmitters.
Due to these various roles, it’s thought that, as bones put on away, osteocalcin ranges drop, contributing to many age-related well being issues, together with diabetes, low muscle mass, and cognitive points.16 17 (At the least, that’s the idea. Most of this analysis has been performed on mice.)
Osteocalcin apart, lack of bone density can, in fact, result in fractures, which may enhance your danger of demise for as much as 10 years after a break.18
It’s particularly essential to maintain tabs on bone well being should you’re in any of those high-risk classes:
- You’re feminine and went via menopause earlier than age 45.
- You’ve been sedentary most of your grownup life.
- You are taking medicines similar to diuretics or stomach-acid blockers, that are linked with an elevated danger of osteoporosis.
- You could have a historical past of nicotine use or extreme alcohol consumption.
- You could have a medical situation, similar to diabetes or thyroid illness, that raises your danger.
- You could have a household historical past of osteoporosis.
▶ The best way to measure it
Twin-energy X-ray absorptiometry (DEXA) scans are a sort of X-ray that measures the quantity of bone mineral content material packed right into a sq. centimeter of bone.
Insurance coverage usually gained’t cowl these scans for individuals youthful than 65 until there’s a documented danger of creating osteoporosis. Out of pocket, the common price is about $300.
If you obtain your DEXA outcomes, you’ll see a T-score that represents how your bone density compares to the common bone density of a younger grownup with peak bone mass. A T-score of +1.0 to -1.0 means you have got regular bone mineral density for somebody your age. Something under -1.0 means you might need osteopenia (low bone mineral density) or osteoporosis (porous bones which are vulnerable to fracture).
Industrial bio age checks
When you have some cash to burn, you may study an terrible lot about your physique.
Right here, you’ll discover a fast run-down on among the extra high-tech checks you will get and what they will let you know.
Nonetheless, earlier than we get into the small print, we need to level out a couple of caveats:
▶ Organic age can fluctuate over time, and by organ. Somebody might undergo a interval of accelerated growing older—saying, throughout a interval of intense stress—then their fee of growing older might sluggish as they focus extra on restoration. Moreover, organs can age at completely different charges. For instance, somebody with coronary heart illness might have a comparatively older coronary heart than their kidneys. (Not all checks measure particular person organ age, nevertheless it’s turning into extra widespread.)
▶ Industrial checks gained’t all the time precisely replicate the modifications you’re making. Till extra analysis helps the reliability of those checks, consider your behaviors over remoted take a look at outcomes. Should you’re consuming extra fruits and veggies, exercising extra constantly, managing stress, and in any other case slaying the wholesome way of life division, don’t sweat your outcomes. Give attention to doing the issues we all know enhance well being.
▶ If an organization pairs your take a look at outcomes with a tough promote for a proprietary and costly complement protocol, be cautious. It’s higher to share and focus on your outcomes with a trusted well being skilled than take well being recommendation from a profit-seeking stranger over the web.
Industrial take a look at #1: DNA methylation
DNA methylation is a organic course of that chemically alters DNA. As a result of the speed of methylation accelerates with growing older, it may be used to estimate somebody’s organic age and life expectancy, finds analysis.19 20 21
The Horvath Clock and DunedinPACE each measure particular biomarkers that can be utilized to raised perceive somebody’s methylation fee. Scientists developed these checks to assist different scientists research how varied way of life elements, environmental exposures, and medicines have an effect on growing older. They didn’t develop the checks as a approach for the common individual to pinpoint their organic age. (Which hasn’t stopped firms from promoting DNA methylation testing kits to the general public.) They price about $300.
Should you resolve to get one among these checks, take into account your outcomes gained’t offer you an entire image of your well being and longevity. Getting old sometimes happens at various charges all through the physique. Your liver would possibly age quicker than your coronary heart or mind, for instance. So should you measure DNA methylation in your blood, that’s all you realize about. Put one other approach, a DNA methylation take a look at isn’t an alternative choice to your annual wellness checkup or blood work.
Industrial take a look at #2: Telomere evaluation
Telomeres—the protecting caps on the ends of chromosomes—put on away with age. The size of a telomere can predict what number of instances a selected cell can divide earlier than dying.
Abnormally quick telomeres are related to a number of genetic ailments. Because of this, when physicians suspect somebody might need inherited a genetic illness, they’ll order a selected kind of telomere take a look at—the flow-FISH take a look at—to measure the telomere size in all of the cells in a blood pattern.22 23
It’s extra debatable whether or not telomere checks can predict growing older in wholesome individuals.
Simply as importantly, the telomere take a look at marketed to the general public, generally known as the qPCR telomere take a look at, isn’t utilized in analysis or medication. These $100 checks are high quality should you’re merely curious—simply don’t base well being and health selections in your outcomes.
Industrial take a look at #3: VO2 Max
For years, solely elite athletes cared about VO2 max, which describes the utmost quantity of oxygen that your physique can use throughout train.
Extra just lately, nevertheless, some consultants have instructed that VO2 max can function a measure for athletes and non-athletes alike to trace the speed at which their our bodies are growing older.
Individuals with excessive VO2 max have a tendency not solely to be extra bodily match but in addition much less prone to develop coronary heart illness, diabetes, most cancers, or stroke.24 25 26 27
In an observational research that adopted the well being outcomes of 5,107 Danish males over 46 years, males with above-average V02 max throughout center age lived a mean of 5 years longer than males with below-average V02 max. Every unit enhance in VO2 max was related to a 45-day enhance in longevity. The researchers instructed VO2 max might extra precisely predict all-cause mortality than excessive ldl cholesterol, weight problems, hypertension, and insulin resistance.28
You would possibly consider V02 max as a canary and your growing older physique as a coal mine.
As you age, your chest wall turns into extra inflexible, the muscle groups that encompass the lungs weaker, and the oxygen-carrying blood vessels calcified and fewer elastic. The guts additionally squeezes with much less power, max coronary heart fee drops, muscle mass and energy decline, the mitochondria in cells and muscle groups lose their effectiveness, amongst different variations.
Along with elevating your danger for a lot of completely different ailments, these modifications also can have an effect on VO2 max, which tends to say no 10 % per decade beginning round age 30.29 30
Previously, the one option to reliably measure VO2 max was in a health lab.
You’d put on a metabolic masks and a coronary heart monitor when you ran or cycled to exhaustion. The masks collected your expired carbon dioxide and monitored how a lot oxygen you sucked into your lungs. This lab-based testing continues to be essentially the most correct option to measure V02 max in addition to different key health metrics similar to:
- Max coronary heart fee, or the very best variety of instances your coronary heart can beat per minute throughout train
- Ventilatory threshold 1, or the purpose throughout train when the physique switches from primarily utilizing fats for gas to utilizing a mixture of fats and glucose or glycogen (saved glucose) for gas.
- Ventilatory threshold 2, or the purpose the place your physique strikes away from cardio metabolism (which makes use of oxygen) to anaerobic metabolism (which doesn’t use oxygen).
- Tidal quantity is the quantity of air inhaled or exhaled throughout every breath
Relying on the place you reside, you would possibly have the ability to get your VO2 max examined for round $150.
Nonetheless, should you don’t have entry to a VO2 max clinic, three considerably much less correct choices exist.
▶ The 1-mile stroll take a look at
Put on a coronary heart fee monitor as you stroll one mile on a flat floor, similar to a treadmill or working observe. As quickly as you full the mile, document your coronary heart fee and stroll time. Then, plug it into the next formulation to calculate your VO2 max:
132.853 — (0.0769 × Weight) — (0.3877 × Age) + (6.315 × Intercourse) — (3.2649 × Time) — (0.1565 × Coronary heart fee)
If that looks like an excessive amount of math, you may as well use a free online tool.
▶ The smartwatch take a look at
Many smartwatches will estimate your VO2 Max for you based mostly on data the watch gathers out of your exercises, intercourse, and age. In comparison with in-office testing, sensible watches can over- or underestimate V02 max, particularly in people who find themselves very out of form or extraordinarily match.31
Due to this, you don’t essentially need to use your sensible watch measurement to find out your present state of well being. Nonetheless, it can assist you to see tendencies. For instance, does your VO2 estimate drop after a couple of weeks of skipping your ordinary spin class? In that case, that’s good data to have.
▶ The PR take a look at
Health efficiency correlates with longevity. Should you’re getting quicker at working a sure distance or can go an extended distance than earlier than, you’re getting fitter and growing your possibilities of dwelling an extended, wholesome life.
One option to take a look at this: the 12-minute run take a look at, often known as the Cooper take a look at. (This can be a validated option to estimate VO2 max—and reveals a few 90 % correlation with lab-based measurements.)
Right here’s the way it works:
Run as quick as you may on a flat floor, similar to a treadmill set at a 1 % incline or working observe, for 12 minutes. After 12 minutes, document your distance. Then, plug it into one of many following formulation to calculate your VO2 max.
Distance in Miles | Distance in Kilometers | |
---|---|---|
VO2 Max = | (35.97 x distance in miles) – 11.29 | (22.351 x distance in kilometers) – 11.288 |
In lieu of doing math, you may as well use a free online calculator.
The best way to change your organic age
Attempt to think about the knowledge you collect about your physique as simply that—data.
It’s not an ethical judgment of who you might be as an individual.
Simply as importantly, it’s not a everlasting state of affairs.
- Should you’re weaker than different individuals your age, you may develop stronger.
- In case your ldl cholesterol or blood glucose ranges are excessive, you may take steps to decrease them.
- In case your physique is growing older quicker than your birthdays, contemplate exploring key way of life modifications that will assist flip the state of affairs round.
You could have choices. Nonetheless, most individuals make two large errors relating to longevity-related way of life modifications.
Mistake #1: Ignoring evergreen, big-impact methods
It’s the straightforward, boring, “I’ve heard this one million instances earlier than” well being practices that, when performed constantly, add as much as an extended, wholesome life.
We’re speaking about issues like…
- Consuming extra minimally processed meals and fewer ultra-processed meals
- Consuming extra brightly coloured fruits and veggies
- Shifting your physique frequently
- Getting sufficient relaxation and sleep
- Having fun with neighborhood, time in nature, and different actions that make life significant
- Retaining alcohol consumption reasonable
- Not utilizing tobacco
- Sporting sunscreen
- Flossing
And that’s only a partial record.
In response to 1000’s of research, individuals who observe these and different high-impact methods not solely reside longer, but in addition reside higher. They’re stronger, happier, and fewer prone to spend their later years disabled or in ache.
(Should you’d wish to see the place you stand relating to large influence well being and longevity methods, try our FREE Longevity Evaluation.)
Nonetheless, relating to well being, health, and longevity, many individuals pursue choices with minimal influence (at finest). They attain for the newest, fashionable complement fairly than taking steps to give up smoking, as only one instance.
Right here’s the factor: Large rock methods require modifications in habits. If every day bodily exercise had been as straightforward as popping a capsule, walkers and cyclists would clog up the streets in your neighborhood.
(It’s exactly this cause why so many individuals want the assist of an authorized well being coach who has undergone coaching within the science of habits change.)
Mistake #2: Not turning knowledge into motion
The info gathered from biomarker growing older checks may give you a way of management.
Nonetheless…
Information, in isolation, doesn’t result in an extended life.
Gathering knowledge with out altering your habits is like checking your reflection within the mirror, seeing spinach wedged between your incisors, and leaving it there.
You must take away the spinach for the mirror examine to be worthwhile.
Biomarker testing is similar.
Should you don’t use your bio knowledge to tell habits change, you’re losing your time and money.
Contemplate your biomarker knowledge as a baseline or place to begin.
Then, use it to evaluate whether or not varied way of life modifications or medical interventions are transferring you nearer to your objective of dwelling an extended, more healthy life.
References
Click on right here to view the knowledge sources referenced on this article.
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